• Anatomical variations in the circle of Willis are associated with increased odds of intracranial aneurysms: The Tromsø study 

      Hindenes, Lars Bakke; Ingebrigtsen, Tor; Isaksen, Jørgen Gjernes; Håberg, Asta; Johnsen, Liv-Hege; Herder, Marit; Mathiesen, Ellisiv B.; Vangberg, Torgil Riise (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-25)
      Purpose: Studies on patients suggest an association between anatomical variations in the Circle of Willis (CoW) and intracranial aneurysms (IA), but it is unclear whether this association is present in the general population. In this cross-sectional population study, we investigated the associations between CoW anatomical variations and IA.<p> <p>Methods: We included 1667 participants from a ...
    • Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population 

      Eriksen, Bjørn Odvar; Løchen, Maja-Lisa; Arntzen, Kjell Arne; Bertelsen, Geir; Eilertsen, Britt-Ann; Hanno, Therese von; Herder, Marit; Jenssen, Trond Geir; Mathisen, Ulla Dorte; Melsom, Toralf; Njølstad, Inger; Solbu, Marit Dahl; Mathiesen, Ellisiv B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11)
      Background/Aims: Estimated GFR (eGFR) is used extensively in epidemiological research. Validations of eGFR have demonstrated acceptable performance, but the dependence of creatinine and cystatin C on non-GFR factors could confound associations with disease. Few studies have investigated this issue in direct comparison with measured GFR (mGFR). We compared the associations between eGFR and mGFR ...
    • Long-Term Use of Lipid-Lowering Drugs Slows Progression of Carotid Atherosclerosis The Tromso Study 1994 to 2008 

      Herder, Marit; Arntzen, Kjell Arne; Johnsen, Stein Harald; Eggen, Anne Elise; Mathiesen, Ellisiv B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Data on the effect of lipid-lowering drugs (LLD) on carotid atherosclerosis outside clinical trials are limited. The aim of this study was to determine the effect of LLD on change in carotid intima media thickness and total plaque area in a general population. Subjects were 1532 women and 1442 men who participated in a longitudinal population-based study with ultrasound examination of intima media ...
    • The metabolic syndrome and progression of carotid atherosclerosis over 13 years. The Tromsø study. 

      Herder, Marit; Arntzen, Kjell Arne; Johnsen, Stein Harald; Mathiesen, Ellisiv B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      The metabolic syndrome (MetS) is associated with increased risk of cardiovascular disease. In this study, we examine if metabolic syndrome predicts progression of atherosclerosis over 13 years. Participants were 1442 men and 1532 women in the population-based Tromsø Study who underwent carotid ultrasound examinations at baseline in the 4th (1994–5) and at follow-up in the 6th survey (2007–8). Of ...
    • Prediction of progression of ultrasound assessed carotid artery athersclerosis 

      Herder, Marit (Doctoral thesis; Doktorgradsavhandling, 2014-03-11)
      Atherosclerosis is an important underlying cause of cardiovascular disease and death. According to the World Health Organization’s Global Burden of Disease Study, ischemic heart disease and stroke combined killed 12.9 million people in 2010, or one in four deaths worldwide. Ultrasound of the carotid arteries can be used to assess the burden of atherosclerosis by measurements of intima-media thickness ...
    • Prevalence of intracranial artery stenosis in a general population using 3D-time of flight magnetic resonance angiography 

      Johnsen, Liv-Hege; Herder, Marit; Vangberg, Torgil Riise; Isaksen, Jørgen Gjernes; Mathiesen, Ellisiv B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-20)
      Background: Data on prevalence of intracranial artery stenosis (ICAS) in Western populations is sparse. The aim of the study was to assess the prevalence and risk factors for ICAS in a mainly Caucasian general population. Methods: We assessed the prevalence of ICAS in 1847 men and women aged 40 to 84 years who participated in a cross-sectional population-based study, using 3-dimensional time-of-flight ...
    • Prevalence of unruptured intracranial aneurysms: impact of different definitions-the Tromsø Study 

      Johnsen, Liv-Hege; Herder, Marit; Vangberg, Torgil Riise; Kloster, Roar; Ingebrigtsen, Tor; Isaksen, Jørgen Gjernes; Mathiesen, Ellisiv B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-10)
      Background - Management of incidental unruptured intracranial aneurysms (UIAs) remains challenging and depends on their risk of rupture, estimated from the assumed prevalence of aneurysms and the incidence of aneurysmal subarachnoid haemorrhage. Reported prevalence varies, and consistent criteria for definition of UIAs are lacking. We aimed to study the prevalence of UIAs in a general population ...
    • Risk Factors for Progression of Carotid Intima-Media Thickness and Total Plaque Area A 13-Year Follow-Up Study: The Tromsø Study 

      Herder, Marit; Johnsen, Stein Harald; Arntzen, Kjell Arne; Mathiesen, Ellisiv B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Data on risk factors for progression of intima-media thickness (IMT) and plaque are scarce. The objective was to determine long-term risk factors for total plaque area (TPA) and IMT as well as risk factors for progression (ΔTPA and ΔIMT). Subjects were 1307 men and 1436 women who participated in a longitudinal population-based study with ultrasound examination of the right carotid artery at baseline ...